I finished Arkham Asylum a few weeks back and since then I've been playing Rock Band: Beatles and Guitar Hero 5. I took a long break from the guitar games but the Beatles got me back in. Plus Rock Band has had some good downloads lately between Pearl Jam and Breaking Benjamin.
I want to pick up the Fallout 3 GOTY edition and some of the other fall titles look promising. Uncharted 2 should be insane.