By now they've probably kicked around a multitude of MacGuffins: a Lewis and Clark relic? D.B. Cooper's money? An Animal House film shoot relic? Map to a Voodoo Donuts with no wait line?
Here's my pitch: Next generation of kids. Human remains are found under someone's house and secured by the same country clubbers from the first film, now claiming to be 1/64 Tillamook Indian (they have exhaustive research). They claim the land and want to build a casino. The new Astoria museum curator disputes the discovery of another
Kennewick Man. So the hunt begins for a rumored Japanese ship which would instead prove Ke Huy Quan's family the only surviving true native people of Astoria.