Haven't played it, but someone on YouTube posted all the cutscenes from the game and here are my favorites (WARNING!!! SPOILERS! Read no further if you haven't played the yet and/or do not like spoilers!):
1. Indy losing his team members at the start one by one, either because they run away, or fall down bottomless pits, or get shot by the Hovitos, and he's too engrossed in the map to notice.
2. The fact Satipo survives the temple sequence is interesting, as is the change in story that he was working for Belloq the whole time rather than just being a greedyguts. Also Bellpq demanding the idol and Indy offering him a friggin' rubber ducky was hilarious, as was Belloq's impression of C-3PO.
3. Toht burning his butt, not his hand, on the headpiece. And, when Indy and Marion escape from the burning Raven, they swipe what I'm guessing is the car Toht came in while the driver is drinking hot chocolate!
4. Sallah's antics in the map room and just about anything involving the minor Germans, esp. them trying to carry the Ark up a flight of stairs and dropping it (!), and the gag with the binoculars.
5. Indy trying to catch Marion when Toht throws her down into the Well of the Souls...and missing by a mile. Ouch. That looked like it had to hurt.
6. The headless German mechanic. Need I say more?
7. The implication that Indy uses a can-opener to get inside the U-boat. Also in the same sequence, the one poor German who gets bonked in the head with the opening door.
8. Marion pretending she has to go to the bathroom and Indy whacking her thoroughly confused guard with a frying pan. The change-up of having her be with Indy on the cliff above the bad guys was also interesting....as was the fact Indy is dissuaded from blowing the Ark up not by Belloq's impassioned speech, but by the sudden appearance, from out of nowhere of about twenty Germans....including one guy hanging upside-down from nothing apparently.
9. The ghosts that come out of the Ark are the classic Lego ghosts. Wonderful, just wonderful. Also God apparently doesn't want Marion and Indy to be together because when they try to get smoochy the last ghost flits between them and dazzles poor Indy with what I can only describe as some (harmless) "wrath of God" pixie dust.
10. And lastly, Major Eaton getting lost in the warehouse.
What I didn't like was how they did the truck chase. Two cargo trucks? The troop car is driven by Sallah? Most of the change-ups in the game were interesting but this bugged me. I wouldn't have minded Sallah swiping the troop car to assist Indy, if there'd been a second, German-occupied one (although since I haven't seen the actual gameplay there may very well be a couple - I just wanted to see Lego's rendition of Gobler's chasm fall is all).
Also the melting head effects when the Ark is opened were a bit of a letdown. However prior to that I thought they managed to handle the awe and splendor of the sequence with the characters' expressions (both amazed and, subsequently, terrified) pretty darn well.