I've stated before but I think Indy V will do somewhere in the ballpark of 600-800 million. Being generous I will give it 850 million, absolute tops. It will not be a success.
Even if there was a new guy in the role, Indiana Jones isn't that big of a franchise anymore, its brand has been out of the public consciousness for a decade (no games, no shows, no books, no comics, etc), and KOTCS did its share of damage. Plus there is no demand for it. Look around the web. Outside of this place there is no buzz or desire for a new film. No one cares anymore. KOTCS rode the nostalgia of Baby Boomers and Gen X and disappointed most - that audience has no desire to be let down again.
Indiana Jones lacks the built-in fanbase that Marvel has. Marvel movies do well because, besides being good, Marvel has built up a massive fandom over 70 years. It is a universe with a lot of different things to offer, and thus a lot of audience - from sci-fi fans (Guardians of the Galaxy) to people who like Nordic mythology (Thor) and everything in between. Indiana Jones is just one man, who, if we're being honest, is baked into the public mind as Harrison Ford, an old man.
Indiana Jones also lacks the massive and almost cult-like fanbase of Star Wars. People WANTED sequels to the original movies, perhaps even more than they wanted the prequels. Where is the demand for Indy V?
Indy films were basically big dumb fun B-movies in an era where nostalgia for the past ruled and Roland Emerich and Michael Bay weren't around yet. Its void has been filled and there is no nostalgia anymore for the 1930s/1960s like there was in the 80s.
Jurassic World was a success because Jurassic Park caught the imagination of the entire planet in 1993. It was an EVENT. The Lost World was also a success and while not as popular as the first, it introduced the franchise to a younger audience with its line of extremely popular toys and McDonalds tie-ins. While Jurassic Park 3 was lackluster, it didn't have 19 years of hype and thus extreme disappointment. Jurassic World also did well because of a viral campaign to re-introduce the franchise to the public which went on for almost a year before the film's release, and it banked on the nostalgia that Millenials have for the first two Jurassic Park films. What nostalgia do Millenials have for Indy? Their only experience with him, in real time anyway, is KOTCS. We grew up with Lara Croft and The Mummy. I've not met many people of my own age who love Indy.
Indiana Jones - not just Harrison Ford - is old hat.