That's kind of spoileriffic for people who haven't played it, isn't it?
This game covers so many quests with different villains and whatnot one could easily make a case for one or two, or perhaps a handful, of possible stories being canonical, while the rest are colorful embellishment of the Indy legend. Which particular quests one might consider canon is up to the individual, of course. I think this should be considered a rather sketchily-defined area in any "official" Indy canon that attempts to include as many things as possible; one can certainly allow for "an adventure in Mexico / Central America in the 1930s," but with no more specificity than that.